Tal pai, tal filho: epigenética em porquinhos da Índia selvagens

quinta-feira, dezembro 24, 2015

Paternal intergenerational epigenetic response to heat exposure in male Wild guinea pigs

Authors

Alexandra Weyrich, Dorina Lenz, Marie Jeschek, Tzu Hung Chung, Kathrin Rübensam, Frank Göritz, Katarina Jewgenow, Jörns Fickel

First published: 19 December 2015Full publication history



Abstract

Epigenetic modifications, of which DNA methylation is the best studied one, can convey environmental information through generations via parental germ lines. Past studies have focused on the maternal transmission of epigenetic information to the offspring of isogenic mice and rats in response to external changes, whereas heterogeneous wild mammals as well as paternal epigenetic effects have been widely neglected. In most wild mammal species, males are the dispersing sex and have to cope with differing habitats and thermal changes. As temperature is a major environmental factor we investigated if genetically heterogeneous Wild guinea pig (Cavia aperea) males can adapt epigenetically to an increase in temperature and if that response will be transmitted to the next generation(s). Five adult male guinea pigs (F0) were exposed to an increased ambient temperature for 2 months, i.e. the duration of spermatogenesis. We studied the liver (as the main thermoregulatory organ) of F0 fathers and F1 sons, and testes of F1 sons for paternal transmission of epigenetic modifications across generation(s). Reduced representation bisulphite sequencing revealed shared differentially methylated regions in annotated areas between F0 livers before and after heat treatment, and their sons’ livers and testes, which indicated a general response with ecological relevance. Thus, paternal exposure to a temporally limited increased ambient temperature led to an ‘immediate’ and ‘heritable’ epigenetic response that may even be transmitted to the F2 generation. In the context of globally rising temperatures epigenetic mechanisms may become increasingly relevant for the survival of species.

FREE PDF GRATIS: Molecular Ecology

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NOTA DESTE BLOGGER:

Lamarck, ei Lamarck! acho que você está sendo vindicado no contexto de justificação teórica, e a evolução já não é mais exclusivamente de Darwin... 

Fui, nem sei por que, rindo da cara de alguns cientistas da Nomenklatura científica que se recusam reconhecer a fragorosa falência epistêmica de Darwin, e da Galera dos meninos e meninas de Darwin que, a cada pesquisa, ficam cada vez mais órfãos - são as evidências que mandam em ciência, e não as teorias!!!