Teoria da informação, previsibilidade, e o surgimento da vida complexa: mero acaso, fortuita necessidade ou design inteligente?

quinta-feira, julho 27, 2017

Information theory, predictability, and the emergence of complex life

Luís F Seoane 1, 2, 3 and Ricard V. Solé 2, 3, 4

1 Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.

2 ICREA-Complex Systems Lab, Universitat Pompeu Fabra (GRIB), Dr Aiguader 80, 08003 Barcelona, Spain.

3 Institut de Biologia Evolutiva, CSIC-UPF, Pg Maritim de la Barceloneta 37, 08003 Barcelona, Spain.

4 Santa Fe Institute, 1399 Hyde Park Road, Santa Fe NM 87501, USA.

Source/Fonte: Jon Lieff


Despite the obvious advantage of simple life forms capable of fast replication, different levels of cognitive complexity have been achieved by living systems in terms of their potential to cope with environmental uncertainty. Against the inevitable cost associated to detecting environmental cues and responding to them in adaptive ways, we conjecture that the potential for predicting the environment can overcome the expenses associated to maintaining costly, complex structures. We present a minimal formal model grounded in information theory and selection, in which successive generations of agents are mapped into transmitters and receivers of a coded message. Our agents are guessing machines and their capacity to deal with environments of different complexity defines the conditions to sustain more complex agents.

Keywords: Complexity, emergence, computation, evolution, predictability


Novos genes e inovação funcional em mamíferos

quarta-feira, julho 26, 2017

New genes and functional innovation in mammals

José Luis Villanueva-Cañas Jorge Ruiz-Orera M.Isabel Agea Maria Gallo David Andreu M.Mar Albà

Genome Biol Evol evx136. DOI: https://doi.org/10.1093/gbe/evx136

Published: 21 July 2017 

Article history

Received: 09 February 2017 Revision Received: 17 May 2017

Revision Received: 29 June 2017 Accepted: 14 July 2017

Source/Fonte: Edvotek


The birth of genes that encode new protein sequences is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions they are selected for. To address these questions we have obtained a large collection of mammalian-specific gene families that lack homologues in other eukaryotic groups. We have combined gene annotations and de novo transcript assemblies from 30 different mamalian species, obtaining about 6,000 gene families. In general, the proteins in mammalian-specific gene families tend to be short and depleted in aromatic and negatively charged residues. Proteins which arose early in mammalian evolution include milk and skin polypeptides, immune response components, and proteins involved in reproduction. In contrast, the functions of proteins which have a more recent origin remain largely unknown, despite the fact that these proteins also have extensive proteomics support. We identify several previously described cases of genes originated de novo from non-coding genomic regions, supporting the idea that this mechanism frequently underlies the evolution of new protein-coding genes in mammals. Finally, we show that most young mammalian genes are preferentially expressed in testis, suggesting that sexual selection plays an important role in the emergence of new functional genes.

de novo gene, species-specific gene, lineage-specific gene, evolutionary innovation, adaptive evolution, mammals

Issue Section: Research article

Author notes

# Current address: Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Barcelona, Spain

© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

FREE PDF GRATIS: Genome Biol Evol Sup. Info.

Da estrutura ao mecanismo - compreendendo a iniciação da replicação do DNA

From structure to mechanism—understanding initiation of DNA replication

Alberto Riera1, Marta Barbon1,2,3, Yasunori Noguchi1,3, L. Maximilian Reuter1,3, Sarah Schneider1,3 and Christian Speck1,2

- Author Affiliations

1DNA Replication Group, Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom;

2Medical Research Council (MRC) London Institute of Medical Sciences (LMS), London W12 0NN, United Kingdom

Corresponding author: chris.speck@imperial.ac.uk

↵3 These authors contributed equally to this work.

Source/Fonte: ThoughtCo


DNA replication results in the doubling of the genome prior to cell division. This process requires the assembly of 50 or more protein factors into a replication fork. Here, we review recent structural and biochemical insights that start to explain how specific proteins recognize DNA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize new DNA strands, and reassemble chromatin. We focus on the minichromosome maintenance (MCM2–7) proteins, which form the core of the eukaryotic replication fork, as this complex undergoes major structural rearrangements in order to engage with DNA, regulate its DNA-unwinding activity, and maintain genome stability.

Keywords MCM2–7 DNA replication pre-RC CMG replisome cryo-EM


Freely available online through the Genes & Development Open Access option.

© 2017 Riera et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

FREE PDF GRATIS: Genes and Development

Darwin, rir é o melhor remédio: momentos desapontadores na evolução!

Source/Fontes: WrongHands

Este blogger achou interessante este site: humor fino!

Controle hidráulico das nadadeiras de tuna: mero acaso, fortuita necessidade ou design inteligente?

Hydraulic control of tuna fins: A role for the lymphatic system in vertebrate locomotion

Vadim Pavlov1,*,†, Benyamin Rosental1,2,*, Nathaniel F. Hansen1, Jody M. Beers1, George Parish3, Ian Rowbotham3, Barbara A. Block1,†

+ See all authors and affiliations

Science 21 Jul 2017:

Vol. 357, Issue 6348, pp. 310-314

Researchers from the lab of Barbara Block at Stanford University and the Monterey Bay Aquarium have discovered a bio-hydraulic system in fins of tunas. (Image credit: Monterey Bay Aquarium)
Source/Fonte: Stanford News

Hydraulic fins

The lymphatic system in fish has much the same function as it does in mammals—immune response and homeostasis. Pavlov et al. show, however, that in the scromboid (tuna and mackerel) family of fish, this fluid homeostasis function has been co-opted to help facilitate dorsal fin rigidity and movement (see the Perspective by Triantafyllou). In bluefin tuna, a series of lymphatic vessels are integrated with muscles that allow the fish to raise and stiffen their dorsal fin. This provides extra stability during swimming.

Science, this issue p. 310; see also p. 251


The lymphatic system in teleost fish has genetic and developmental origins similar to those of the mammalian lymphatic system, which is involved in immune response and fluid homeostasis. Here, we show that the lymphatic system of tunas functions in swimming hydrodynamics. Specifically, a musculo-vascular complex, consisting of fin muscles, bones, and lymphatic vessels, is involved in the hydraulic control of median fins. This specialization of the lymphatic system is associated with fish in the family Scombridae and may have evolved in response to the demand for swimming and maneuvering control in these high-performance species.


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Especialistas advertem: fazer campanha sobre o consenso da ciência do clima pode sair pela culatra!

terça-feira, julho 25, 2017

Beyond Counting Climate Consensus

Warren Pearce, Reiner Grundmann ORCID Icon, Mike Hulme, Sujatha Raman, Eleanor Hadley Kershaw & Judith Tsouvalis

Pages 1-8 | Received 27 Aug 2016, Accepted 30 Apr 2017, Published online: 23 Jul 2017

Download citation http://dx.doi.org/10.1080/17524032.2017.1333965


Several studies have been using quantified consensus within climate science as an argument to foster climate policy. Recent efforts to communicate such scientific consensus attained a high public profile but it is doubtful if they can be regarded successful. We argue that repeated efforts to shore up the scientific consensus on minimalist claims such as “humans cause global warming” are distractions from more urgent matters of knowledge, values, policy framing and public engagement. Such efforts to force policy progress through communicating scientific consensus misunderstand the relationship between scientific knowledge, publics and policymakers. More important is to focus on genuinely controversial issues within climate policy debates where expertise might play a facilitating role. Mobilizing expertise in policy debates calls for judgment, context and attention to diversity, rather than deferring to formal quantifications of narrowly scientific claims.

FREE PDF GRATIS: Environmental Communication

Os tardígrados (ursos-d'água) sobreviverão ao fim do mundo que nós conhecemos

sexta-feira, julho 21, 2017

The Resilience of Life to Astrophysical Events

David Sloan, Rafael Alves Batista & Abraham Loeb

Scientific Reports 7, Article number: 5419 (2017)

Download Citation

Astrobiology Exoplanets

Received: 18 January 2017 Accepted: 05 June 2017 

Published online: 14 July 2017

Source/Fonte: Science News


Much attention has been given in the literature to the effects of astrophysical events on human and land-based life. However, little has been discussed on the resilience of life itself. Here we instead explore the statistics of events that completely sterilise an Earth-like planet with planet radii in the range 0.5–1.5R⊕ and temperatures of ∼300 K, eradicating all forms of life. We consider the relative likelihood of complete global sterilisation events from three astrophysical sources – supernovae, gamma-ray bursts, large asteroid impacts, and passing-by stars. To assess such probabilities we consider what cataclysmic event could lead to the annihilation of not just human life, but also extremophiles, through the boiling of all water in Earth’s oceans. Surprisingly we find that although human life is somewhat fragile to nearby events, the resilience of Ecdysozoa such as Milnesium tardigradum renders global sterilisation an unlikely event.


D.S. and R.A.B. acknowledge the financial support from the John Templeton Foundation.

Author information


Department of Physics - Astrophysics, University of Oxford, Denys Wilkinson Building, Keble Road, OX1 3RH, Oxford, UK

David Sloan & Rafael Alves Batista

Astronomy Department, Harvard University, 60 Garden Street, Cambridge, MA, 02138, USA

Abraham Loeb


The idea of this work was conceived by A.L., D.S. and R.A.B. contributed equally to the analysis of results, with some input from A.L. D.S. did most of the writing, with aid of R.A.B. Figures were produced by R.A.B., A.L. was responsible for the scope and accuracy checking of the analysis.

Competing Interests

The authors declare that they have no competing interests.

Corresponding author

Correspondence to Rafael Alves Batista.

FREE PDF GRATIS: Science Reports

Sacudindo o paradigma da matéria escura

quinta-feira, julho 20, 2017

Shaking the dark matter paradigm

07/18/17 By Ali Sundermier

A theory about gravity challenges our understanding of the universe.

Illustration by Ana Kova

For millennia, humans held a beautiful belief. Our planet, Earth, was at the center of a vast universe, and all of the planets and stars and celestial bodies revolved around us. This geocentric model, though it had floated around since 6th century BCE, was written in its most elegant form by Claudius Ptolemy in 140 AD.

When this model encountered problems, such as the retrograde motions of planets, scientists reworked the data to fit the model by coming up with phenomena such as epicycles, mini orbits.

It wasn’t until 1543, 1400 years later, that Nicolaus Copernicus set in motion a paradigm shift that would give way to centuries of new discoveries. According to Copernicus’ radical theory, Earth was not the center of the universe but simply one of a long line of planets orbiting around the sun.

But even as evidence that we lived in a heliocentric system piled up and scientists such as Galileo Galilei perfected the model, society held onto the belief that the entire universe orbited around Earth until the early 19th century.

To Erik Verlinde, a theoretical physicist at the University of Amsterdam, the idea of dark matter is the geocentric model of the 21st century. 

“What people are doing now is allowing themselves free parameters to sort of fit the data,” Verlinde says. “You end up with a theory that has so many free parameters it's hard to disprove.”

Dark matter, an as-yet-undetected form of matter that scientists believe makes up more than a quarter of the mass and energy of the universe, was first theorized when scientists noticed that stars at the outer edges of galaxies and galaxy clusters were moving much faster than Newton’s theory of gravity said they should. Up until this point, scientists have assumed that the best explanation for this is that there must be missing mass in the universe holding those fast-moving stars in place in the form of dark matter. 

But Verlinde has come up with a set of equations that explains these galactic rotation curves by viewing gravity as an emergent force — a result of the quantum structure of space.

The idea is related to dark energy, which scientists think is the cause for the accelerating expansion of our universe. Verlinde thinks that what we see as dark matter is actually just interactions between galaxies and the sea of dark energy in which they’re embedded.

“Before I started working on this I never had any doubts about dark matter,” Verlinde says. “But then I started thinking about this link with quantum information and I had the idea that dark energy is carrying more of the dynamics of reality than we realize.”

Verlinde is not the first theorist to come up with an alternative to dark matter. Many feel that his theory echoes the sentiment of physicist Mordehai Milgrom’s equations of “modified Newtonian dynamics,” or MOND. Just as Einstein modified Newton’s laws of gravity to fit to the scale of planets and solar systems, MOND modifies Einstein’s laws of gravity to fit to the scale of galaxies and galaxy clusters.

Verlinde, however, makes the distinction that he’s not deriving the equations of MOND, rather he’s deriving what he calls a “scaling relation,” or a volume effect of space-time that only becomes important at large distances. 

Stacy McGaugh, an astrophysicist at Case Western Reserve University, says that while MOND is primarily the notion that the effective force of gravity changes with acceleration, Verlinde’s ideas are more of a ground-up theoretical work.

“He's trying to look at the structure of space-time and see if what we call gravity is a property that emerges from that quantum structure, hence the name emergent gravity,” McGaugh says. “In principle, it's a very different approach that doesn't necessarily know about MOND or have anything to do with it.”

One of the appealing things about Verlinde’s theory, McGaugh says, is that it naturally produces evidence of MOND in a way that “just happens.” 

“That's the sort of thing that one looks for,” McGaugh says. “There needs to be some basis of why MOND happens, and this theory might provide it.”

Verlinde’s ideas have been greeted with a fair amount of skepticism in the scientific community, in part because, according to Kathryn Zurek, a theoretical physicist at the US Department of Energy’s Lawrence Berkeley National Laboratory, his theory leaves a lot unexplained. 

“Theories of modified gravity only attempt to explain galactic rotation curves [those fast-moving planets],” Zurek says. “As evidence for dark matter, that's only one very small part of the puzzle. Dark matter explains a whole host of observations from the time of the cosmic microwave background when the universe was just a few hundred thousand years old through structure formation all the way until today.”

Read more here/Leia mais aqui: Symmetry

Alô ETs, disquem 0800-NASA e digam alô: a prevalência de espécies tecnológicas no universo

quarta-feira, julho 19, 2017

A New Empirical Constraint on the Prevalence of Technological Species in the Universe

To cite this article:

Frank A. and Sullivan W.T. III. Astrobiology. May 2016, 16(5): 359-362. https://doi.org/10.1089/ast.2015.1418

Source/Fonte: Revista Exame

Published in Volume: 16 Issue 5: May 13, 2016

Online Ahead of Print: April 22, 2016

A. Frank1 and W.T. Sullivan III2

1Department of Physics and Astronomy, University of Rochester, Rochester, New York.

2Department of Astronomy and Astrobiology Program, University of Washington, Seattle, Washington.

Address correspondence to:

A. Frank

Department of Physics and Astronomy

University of Rochester

Rochester, NY 14620

E-mail: afrank@pas.rochester.edu

Submitted 5 October 2015

Accepted 16 February 2016


In this article, we address the cosmic frequency of technological species. Recent advances in exoplanet studies provide strong constraints on all astrophysical terms in the Drake equation. Using these and modifying the form and intent of the Drake equation, we set a firm lower bound on the probability that one or more technological species have evolved anywhere and at any time in the history of the observable Universe. We find that as long as the probability that a habitable zone planet develops a technological species is larger than ∼10−24, humanity is not the only time technological intelligence has evolved. This constraint has important scientific and philosophical consequences. 

Key Words: Life—Intelligence—Extraterrestrial life. 

Astrobiology 2016, 359–362.

FREE PDF GRATIS: Astrobiology

Engenheiros eliminaram uma lei científica centenária descrevendo como o fluido flui através das rochas

Dynamic fluid connectivity during steady-state multiphase flow in a sandstone

Catriona A. Reynolds a,b,1, Hannah Menke a,b, Matthew Andrew c, Martin J. Blunt a,b, and Samuel Krevor a,b

Author Affiliations

aDepartment of Earth Science and Engineering, Imperial College London, London SW7 2AZ, United Kingdom;
bQatar Carbonates and Carbon Storage Research Centre, Imperial College London, London SW7 2AZ, United Kingdom;
cCarl Zeiss X-ray Microscopy Ltd., Pleasanton, CA 94588
Edited by David A. Weitz, Harvard University, Cambridge, MA, and approved June 21, 2017 (received for review February 18, 2017)


The movement of immiscible fluids through permeable media occurs in many settings, including oil and water flow through rock. Here we present observations of a previously unidentified type of steady-state flow behavior that we term “dynamic connectivity.” We demonstrate that flow of the nonwetting phase occurs through a network of connections that continuously rearrange between filled pores. This observation suggests that we need to modify our models of two-phase flow that are fundamental to describing subsurface flow processes such as geologic CO2 storage and hydrocarbon recovery.


The current conceptual picture of steady-state multiphase Darcy flow in porous media is that the fluid phases organize into separate flow pathways with stable interfaces. Here we demonstrate a previously unobserved type of steady-state flow behavior, which we term “dynamic connectivity,” using fast pore-scale X-ray imaging. We image the flow of N2 and brine through a permeable sandstone at subsurface reservoir conditions, and low capillary numbers, and at constant fluid saturation. At any instant, the network of pores filled with the nonwetting phase is not necessarily connected. Flow occurs along pathways that periodically reconnect, like cars controlled by traffic lights. This behavior is consistent with an energy balance, where some of the energy of the injected fluids is sporadically converted to create new interfaces.

steady state pore-scale imaging immiscible two-phase flow dynamic connectivity geologic CO2 storage

1To whom correspondence should be addressed. Email: catriona.reynolds11@imperial.ac.uk.

Author contributions: C.A.R. designed research; C.A.R., H.M., and M.A. performed research; C.A.R. and H.M. analyzed data; and C.A.R., H.M., M.A., M.J.B., and S.K. wrote the paper.

The authors declare no conflict of interest.

This article is a PNAS Direct Submission.

This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1702834114/-/DCSupplemental.

Freely available online through the PNAS open access option.


Universidade laica afasta o dogma e respeita a diferença: será???

Universidade laica afasta o dogma e respeita a diferença
18 de julho de 2017

Imagem meramente ilustrativa

A premissa de que os profissionais envolvidos no sistema público de ensino devem ser preparados para apartar os dogmas religiosos do cotidiano das salas de aula norteou a discussão da mesa-redonda Formação de professores na universidade laica, realizada na tarde de segunda-feira, 17, durante a 69ª Reunião Anual da SBPC.

“A universidade não é o lugar do dogma. A circulação do saber crítico deve prevalecer sobre toda crença que se pretenda impor como uma verdade absoluta”, defendeu o professor Carlos Roberto Jamil Cury, da pós-graduação em Educação da PUC Minas.

Em seu pronunciamento, o educador defendeu que a educação no âmbito do estado deve ser “expressão de cidadania aberta”, evocando noções presentes no texto da Constituição Federal, alinhadas com o combate a todos os tipos de preconceito. “Compatíveis com a Lei brasileira, que nos protege de diferencialismos segregadores, as diretrizes curriculares têm como princípio formar docentes compromissados com o projeto social, político e ético de nação, valorizando, dessa forma, a diversidade e a emancipação dos indivíduos”.


Teoria de informação lógica: novas fundações lógicas para a teoria da informação

Logical Information Theory: New Logical Foundations for Information Theory

Ellerman, David (2017) 

Logical Information Theory: New Logical Foundations for Information Theory. [Preprint]


Here is a new theory of information based on logic. The definition of Shannon entropy as well as the notions on joint, conditional, and mutual entropy as defined by Shannon can all be derived by a uniform transformation from the corresponding formulas of logical information theory. Information is first defined in terms of sets of distinctions without using any probability measure. When a probability measure is introduced, the logical entropies are simply the values of the (product) probability measure on the sets of distinctions. The compound notions of joint, conditional, and mutual entropies are obtained as the values of the measure, respectively, on the union, difference, and intersection of the sets of distinctions. These compound notions of logical entropy satisfy the usual Venn diagram relationships (e.g., inclusion-exclusion formulas) since they are values of a measure (in the sense of measure theory). The uniform transformation into the formulas for Shannon entropy is linear so it explains the long-noted fact that the Shannon formulas satisfy the Venn diagram relations--as an analogy or mnemonic--since Shannon entropy is not a measure (in the sense of measure theory) on a given set.

What is the logic that gives rise to logical information theory? Partitions are dual (in a category-theoretic sense) to subsets, and the logic of partitions was recently developed in a dual/parallel relationship to the Boolean logic of subsets (the latter being usually mis-specified as the special case of "propositional logic"). Boole developed logical probability theory as the normalized counting measure on subsets. Similarly the normalized counting measure on partitions is logical entropy--when the partitions are represented as the set of distinctions that is the complement to the equivalence relation for the partition.

In this manner, logical information theory provides the set-theoretic and measure-theoretic foundations for information theory. The Shannon theory is then derived by the transformation that replaces the counting of distinctions with the counting of the number of binary partitions (bits) it takes, on average, to make the same distinctions by uniquely encoding the distinct elements--which is why the Shannon theory perfectly dovetails into coding and communications theory.


A controvérsia sobre o DNA lixo continua: 75% é lixo, segundo Dan Graur.

terça-feira, julho 18, 2017

An upper limit on the functional fraction of the human genome 

Dan Graur

Genome Biol Evol evx121. DOI: https://doi.org/10.1093/gbe/evx121

Published: 11 July 2017 Article history

Received: 25 March 2017 Revision Received: 20 June 2017

Accepted: 28 June 2017


For the human population to maintain a constant size from generation to generation, an increase in fertility must compensate for the reduction in the mean fitness of the population caused, among others, by deleterious mutations. The required increase in fertility due to this mutational load depends on the number of sites in the genome that are functional, the mutation rate, and the fraction of deleterious mutations among all mutations in functional regions. These dependencies and the fact that there exists a maximum tolerable replacement level fertility can be used to put an upper limit on the fraction of the human genome that can be functional. Mutational load considerations lead to the conclusion that the functional fraction within the human genome cannot exceed 25%, and is probably considerably lower.

Issue Section: Research article

© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

A bifurcação na estrada para o conserto do DNA

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

Shin-Ya Isobe, Koji Nagao, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse5,

5Lead Contact

Open Access

Article Info

Publication History

Published: July 11, 2017 Accepted: June 21, 2017

Received in revised form: April 24, 2017 Received: October 7, 2016

User License

Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)


• SCAI slowly accumulates at damaged sites depending on 53BP1

• 53BP1 S/TP phosphorylation sites are critical for SCAI binding

• SCAI can inhibit RIF1 function

• SCAI facilitates BRCA1-mediated DNA repair


DNA double-strand breaks (DSBs) are repaired by either the homology-directed repair (HDR) or the non-homologous end-joining (NHEJ) pathway. RIF1 (RAP1-interacting factor homolog) was recently shown to stimulate NHEJ through an interaction with 53BP1 (p53-binding protein 1) phosphorylated at S/TQ sites, but the molecular mechanism underlying pathway choice remains unclear. Here, we show that SCAI (suppressor of cancer cell invasion) binds to 53BP1 phosphorylated at S/TP sites and facilitates HDR. Upon DNA damage, RIF1 immediately accumulates at damage sites and then gradually dissociates from 53BP1 and is subsequently replaced with SCAI. Depletion of SCAI reduces both the accumulation of HDR factors, including BRCA1 (breast cancer susceptibility gene 1), at damage sites and the efficiency of HDR, as detected by a reporter assay system. These data suggest that SCAI inhibits RIF1 function to allow BRCA1-mediated repair, which possibly includes alt-NHEJ and resection-dependent NHEJ in G1, as well as HDR in S/G2.


DNA double-strand breaks, BRCA1, RIF1, 53BP1, SCAI, NHEJ, HDR, alternative NHEJ, resection-dependent NHEJ, genomic instability


Uma alternativa legal às publicações acadêmicas pagas

domingo, julho 16, 2017

A legal alternative to academic publishing paywalls

April 12, 2017 1:40 AM   Subscribe

Unpaywall is a web browser extension which finds free versions of paywalled or fee-to-view articles. Launched in early April, it provides an interface to a database of 86+ million digital object identifiers (DOIs). When an Unpaywall user lands on the page of a research article, the software scours thousands of institutional repositories, preprint servers, and websites like PubMed Central to see if an open-access copy of the article is available. If it is, users can click a small green tab on the side of the screen to view a PDF. The developers say Unpaywall doesn't ask for, track or store any personal information. Developed by Impactstory and funded by the National Science Foundation and the Alfred P. Sloan Foundation. Alternatives are available...

Read more/Leia mais aqui: MetaFilter

Micro ondas revelam estrutura detalhada de motor molecular artificial: mero acaso, fortuita necessidade ou design inteligente?

sexta-feira, julho 14, 2017

Cold Snapshot of a Molecular Rotary Motor Captured by High-Resolution Rotational Spectroscopy


Dr. Sérgio R. Domingos, Dr. Arjen Cnossen, Prof. Dr. Wybren J. Buma, Prof. Dr. Wesley R. Browne, Prof. Dr. Ben L. Feringa, Prof. Dr. Melanie Schnell

First published: 20 June 2017 Full publication history

DOI: 10.1002/anie.201704221 View/save citation


We present the first high-resolution rotational spectrum of an artificial molecular rotary motor. By combining chirped-pulse Fourier transform microwave spectroscopy and supersonic expansions, we captured the vibronic ground-state conformation of a second-generation motor based on chiral, overcrowded alkenes. The rotational constants were accurately determined by fitting more than 200 rotational transitions in the 2–4 GHz frequency range. Evidence for dissociation products allowed for the unambiguous identification and characterization of the isolated motor components. Experiment and complementary quantum-chemical calculations provide accurate geometrical parameters for the C27H20 molecular motor, the largest molecule investigated by high-resolution microwave spectroscopy to date.

FREE PDF GRATIS: Angewandte Chemie

Cientistas descobrem que é mais bem aventurado dar do que receber...

A neural link between generosity and happiness

Soyoung Q. Park, Thorsten Kahnt, Azade Dogan, Sabrina Strang, Ernst Fehr & Philippe N. Tobler

Nature Communications 8, Article number: 15964 (2017)

Download Citation

Cooperation Human behaviour

Received: 21 October 2016 Accepted: 12 May 2017

Published online: 11 July 2017


Generous behaviour is known to increase happiness, which could thereby motivate generosity. In this study, we use functional magnetic resonance imaging and a public pledge for future generosity to investigate the brain mechanisms that link generous behaviour with increases in happiness. Participants promised to spend money over the next 4 weeks either on others (experimental group) or on themselves (control group). Here, we report that, compared to controls, participants in the experimental group make more generous choices in an independent decision-making task and show stronger increases in self-reported happiness. Generous decisions engage the temporo-parietal junction (TPJ) in the experimental more than in the control group and differentially modulate the connectivity between TPJ and ventral striatum. Importantly, striatal activity during generous decisions is directly related to changes in happiness. These results demonstrate that top–down control of striatal activity plays a fundamental role in linking commitment-induced generosity with happiness.


This work was supported by grant 0036/AB16 from the Templeton World Charity Foundation, grants PP00P1_128574, PP00P1_150739, 00014_165884 and CRSII3_141965 from the Swiss National Science Foundation and grants PA-2682/1-1 and INST 392/125-1 (Project C07 from SFB/TRR 134) from the German Research Foundation. We thank Christine Schneider and Michel Wälti for their help with data acquisition, Gabriele Bellucci for methodological support and Tamara Jean Herz for language editing. We also gratefully acknowledge the support of the Neuroscience Center Zurich.

Author information


Department of Psychology I, University of Lübeck, Lübeck 23562, Germany
Soyoung Q. Park & Sabrina Strang

Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Thorsten Kahnt

Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Zurich 8006, Switzerland
Azade Dogan, Ernst Fehr & Philippe N. Tobler


S.Q.P., T.K. and P.N.T. conceived and designed the study. S.Q.P., T.K. and A.D. conducted the experiments and analysed the data. S.Q.P., T.K., S.S., E.F. and P.N.T. wrote the manuscript and S.Q.P., T.K., S.S., E.F. and P.N.T. edited the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Soyoung Q. Park.

As cinco grandes extinções em massa

The big five mass extinctions

Biologists suspect we’re living through the sixth major mass extinction. Earth has witnessed five, when more than 75% of species disappeared. Palaeontologists spot them when species go missing from the global fossil record, including the iconic specimens shown here. “We don’t always know what caused them but most had something to do with rapid climate change”, says Melbourne Museum palaeontologist Rolf Schmidt.

End Ordovician, 444 million years ago, 86% of species lost

— Graptolite 2-3 cm length

Graptolites, like most Ordovician life, were sea creatures. They were filter-feeding animals and colony builders. Their demise over about a million years was probably caused by a short, severe ice age that lowered sea levels, possibly triggered by the uplift of the Appalachians. The newly exposed silicate rock sucked CO2 out of the atmosphere, chilling the planet.


Late Devonian, 375 million years ago, 75% of species lost
— Trilobite, 5 cm length

Trilobites were the most diverse and abundant of the animals that appeared in the Cambrian explosion 550 million years ago. Their great success was helped by their spiky armour and multifaceted eyes. They survived the first great extinction but were nearly wiped out in the second. The likely culprit was the newly evolved land plants that emerged, covering the planet during the Devonian period. Their deep roots stirred up the earth, releasing nutrients into the ocean. This might have triggered algal blooms which sucked oxygen out of the water, suffocating bottom dwellers like the trilobites.


Read more here/Leia mais aqui: Cosmos Magazine